Biography

B.S. in Pharmacy from the University of Belgrade;

Ph.D. in Pharmacology from the University of Illinois at Chicago;

Postdoctoral/American Heart Association fellow, Hematology from Washington University in St Louis

General Pharmacology

Molecular and Cellular Ppharmacology

Hemostasis and Thrombosis

Favorite courses:

Pharmacology

 

Scholarly interest:

My research is in the field of thrombosis and hemostasis. In particular, I am interested in molecular mechanisms and molecular pharmacology of platelet functions. Blood platelets play critical roles in the development and course of thrombotic diseases. Thus, thorough understanding of platelet functions at a molecular level is needed to improve existing or introduce novel therapies for cardiovascular diseases.

My current projects investigate:

1. The role of phosphatidylinositol (3,4) bisphosphate in platelet functions
2. Regulation of adenosine diphosphate-mediated platelet activation

 

2007-2008: American Heart Association Heartland Affiliate Postdoctoral Fellowship Award

2003-2005: American Heart Association Greater Midwest Affiliate Predoctoral Fellowship Award

 

Publications:

 

1. Zou J, Chang SC, Marjanovic J, Majerus PW: MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis, J Biol Chem. 2009 Jan 23; 284(4):2064-71 
2. Marjanovic JA, Stojanovic A, Brovkovych V, Skidgel RA, Du X: Post-translational Activation of Inducible Nitric Oxide Synthase by Platelet Activation Signals, J Biol Chem. 2008 Oct 24;283(43):28827-34
3. Majerus PW, Zou J, Marjanovic J, Kisseleva MV, Wilson MP: The role of inositol signaling in the control of apoptosis, Adv Enzyme Regul. 2008;48:10-7
4. Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW: Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16834-9
5. Stojanovic A, Marjanovic JA, Brovkovych V, Peng X, Hay N, Skidgel RA, Du X: A phsophoinositide 3-kinase-Akt-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation, J Biol Chem. 2006, Jun 16; 281(24): 16333-9
6. Marjanovic JA, Li Z, Stojanovic A, Du X: Stimulatory Roles of Nitric Oxide Synthase 3 and Guanylyl Cyclase in Platelet Activation, J Biol Chem. 2005 Nov 11; 280(45): 37430-37439
7. Li Z, Zhang G, Marjanovic JA, Ruan C, Du X: A Platelet Secretion Pathway Mediated by cGMP-dependent Protein Kinase, J Biol Chem. 2004 Oct 8; 279(41): 42469-7
8. Du X, Marjanovic JA, Li Z: On the Roles of cGMP and Glycoprotein Ib in Platelet Activation, Blood. 2004 Jun 1; 103(11): 4371-2
9. Li Z, Ajdic J, Eigenthaler M, Du X: A Predominant Role for cAMP-dependent Protein Kinase in the cGMP-induced Phosphorylation of Vasodilator-stimulated Phosphoprotein and Platelet Inhibition in Humans, Blood. 2003 Jun 1; 101(11): 4423-9